Kriteria diagnosis sle systemic lupus erythematosus. Juanmanuel anaya, 1,2 yehuda shoenfeld, 3 and ricard cervera 4. Istilah lupus erythematosus pernah digunakan pada zaman yunani kuno untuk menyatakan suatu penyakit kulit kemerahan di sekitar pipi yang disebabkan oleh gigitan anjing. Jenis penyakit ini menyerang berbagai jaringan seperti, sendi, kulit, otak, paruparu, ginjal, dan pembuluh darah. Lupus eritematosus sistemik wikipedia bahasa indonesia. Systemic lupus erythematosus sle is the prototypic multisystem. Glossary lupus treatment resources lupus research alliance. Sledai ini telah banyak mengalami perubahan dan versi.
Lesions may be part of systemic lupus or may represent discoid lupus without organ involvement, which is a separate diagnostic entity. Systemic lupus international collaborating clinics american college of rheumatology 365 damage index for systemic lupus erythematosus item ocular either eye, by clinical assessment any cataract ever retinal change or optic atrophy neuropsychiatnc cognitive impairment e. Systemic lupus erythematoses 1 dr jayakrishnan mp pg resident, internal medicine mgm medical college, indore 2. Laporan kasus cutaneus discoid lupus erythematosus. In recent years, many studies have demonstrated an important role of gut microbes in the. Systemic lupus erythematosus sle is a chronic multisystem autoimmune disorder that has a predilection for young women. Treatment of npsle may combine therapy directed at an underlying. It has been considered the great imitator of many different diseases. In lupus, the bodys immune system, which normally functions to protect against foreign invaders, becomes. Lupus was fi rst recognised as a systemic disease with visceral manifestations by moriz kaposi 18371902. Penyakit ini berhubungan dengan deposisi autoantibodi dan kompleks imun, sehingga mengakibatan kerusakan jaringan. Causes and predictors of death in south africans with. The complement system in systemic lupus erythematosus. Systemic lupus erythematosus, anemia, jaundice, autoimmune.
Lupus merupakan penyakit yang terkait dengan kekebalan tubuh manusia. Jenis lupus yang menjadi pembahasan utama dalam artikel ini adalah lupus eritematosus sistemik systemic lupus erythematosus sle. Various parameters of health and disease have been found to be associated with the variation in the human gut microbiome. Systemic lupus erythematosus sle adalah suatu penyakit inflamasi autoimun dengan manifestasi klinis, perjalanan penyakit, dan prognosis yang beragam. During the course of the disease, decreased serum levels of c3, c4 and high antidouble stranded antids dna antibody titers are reported to be associated with the disease activity and poor survival 3. Systemic lupus erythematosus is a useful reference for specialists in the diagnosis and management of patients with sle, a tool for measurement of clinical activity for pharmaceutical development and basic research of the disease and a reference work for hospital libraries. Systemic lupus erythematosus sle is a chronic, multisystem, inflammatory disorder of autoimmune etiology, occurring predominantly in young women. Sle adalah jenis lupus yang paling sering dialami orang. An update on treatment and management of pediatric systemic. Oleh karena itu penyakit lupus ini sulit terdeteksi karena tanda dan gejalanya seringkali mirip dengan penyakit lain. A upon repeated immunostimulation with an antigen such as ova, 100% of mice developed autoimmune diseases characterized by the presence of a variety of autoantibodies and immune tissue injury, including immune complexmediated glomerulonephritis and a positive skin lupus band test. The inflammation triggered by sle affect many organs in the body. Systemic lupus erythematosus this booklet is for people who have systemic lupus erythematosus, commonly called sle or lupus, as well as for their family and friends and others who want to better understand the disease. Systemic lupus erythematosus india pdf ppt case reports.
Penyakit systemic lupus erythematosus sle adalah salah satu penyakit yang terkait dengan sistem imun. Jun 19, 2015 systemic lupus erythematosus sle is an autoimmune disease with a prevalence of 36. Saat ini, belum ada obat yang pasti untuk menyembuhkan penyakit demensia. Lupus can affect any part of the body most commonly the skin, muscles, joints causing inflammation and tissue damage. Symptoms vary between people and may be mild to severe. New classification criteria for sle have greater sensitivity and therefore improve the diagnostic certainty for some patients, especially those who may previously have been labelled as having undifferentiated symptoms.
This is a pdf file of an unedited manuscript that has. Systemic lupus erythematosus sle adalah suatu kelainan autoimun multisistem kronik yang ditandai oleh autoantibodi dan kompleks imun yang berkaitan dengan manifestasi klinis dan kerusakan jaringan yang beragam dan luas. Sistemik lupus erythematosus adalah suatu penyakit kulit menahun yang ditandai dengan peradangan dan pembetukan jaringan parut yang terjadi pada wajah, telinga, kulit kepala dan kandung pada bagian tubuh lainnya. Because of its wide range of symptoms, people often confuse lupus with other health problems. Kondisi pasien mungkin berfluktuasi dan berakibat fatal jika tidak segera diobati saat berkobar. A final estimated figure of 415 patients was obtained, giving a point prevalence on august 1, 1993 of 25.
It can affect the skin, joints, kidneys, brain, and other organs. Background and aims studying the distribution of sle across geographic regions using a big datadriven approach may facilitate understanding of the corresponding genetic and environmental underpinnings. Secara klinis, sle merupakan suatu penyakit kambuhan, dan sulit diperkirakan awal manifestasi secara. Banyak faktor yang memengaruhi terjadinya kasus sle di indonesia, antara lain belum terpenuhinya kebutuhan pasien dan keluarganya tentang informasi, pendidikan, dan dukungan yang terkait dengan sle. Sle has been recognized as a defined clinical entity for more than 100 years. Cutaneous lupus erythematosus clinical and laboratory. Systemic lupus erythematosus page 1 systemic lupus erythematosus lupus systemic lupus erythematosus, referred to as sle or lupus, is sometimes called the great imitator.
However, its cause remains unknown and its treatment options are still limited. The complement system is a doubleedged sword in lupus figure 1. The microbiome and systemic lupus erythematosus springerlink. Lupus nephritis is kidney inflammation caused by systemic lupus erythematosus sle or lupus. Doc systemic lupus erythematosus sle alifah f izzah. Subacute cutaneous lupus erythematosus is an intermediate form of lupus in which skin lesions are mild, without discoid appearance, do not scar, and are usually accompanied with some degree of musculoskeletal involvement. Lesions are discshaped, erythematous plaques of varying size. Dinamakan lupus sistemik dikarenakan terjadi pada berbagai organ, terutama sendi, ginjal, dan kulit.
Systemic lupus erythematosus jurnal keperawatan indonesia ui. Advances in the early serological detection of antinuclear antibodies coupled with discovery of a variety of immunosuppressive agents, including corticosteroids, have had a major positive impact on the outcome of the disease over the last 50 years. This report studies the global systemic lupus erythematosus treatment market size, industry status and forecast, competition landscape and growth opportunity. Systemic lupus erythematosus sle, merupakan penyakit autoimun yang ditandai dengan produksi antibodi terhadap komponen inti sel. He also used the term lupus erythematosus and published the fi rst illustrations in his atlas of skin diseases in 1856. Doc makalah imunhema systemis lupus erythematosus sle. Acute cutaneus lupus erythematosus acle dapat timbul secara erupsi lokal atau difus.
Apr 29, 2019 the most important tool in the medical care of the patient with systemic lupus erythematosus sle is careful and frequent clinical and laboratory evaluation to tailor the patients medical regimen and to provide prompt recognition and treatment of disease flare, which is the cornerstone of successful intervention. Systemic lupus erythematosus msd manual consumer version. Lupus, technically known as systemic lupus erythematosus sle, is an autoimmune disease in which the bodys immune system mistakenly attacks healthy. The microbiota, which is comprised of the collective of all microbes inhabiting the gut and its effect on the human host in which it resides, has become a growing field of interest. Systemic lupus erythematosus genetics home reference nih. The systemic lupus erythematosus treatment market report provides indepth analysis and insights into developments impacting businesses and enterprises on a global and regional level.
Living with lupus donald thomas, md, facp, facr author of the lupus encyclopedia. Beberapa defek dari komponen imunologi multipel berperan penting dalam patogenesis sle. Lupus, technically known as systemic lupus erythematosus sle, is an autoimmune disease in which the bodys immune system mistakenly attacks healthy tissue in many parts of the body. Systemic lupus erythematosus is an autoimmune disease that affects many systems, including the skin, musculoskel etal, renal, neuropsychiatric, hematologic, cardiovascular, pulmonary, and reproductive systems.
Patient has never been well since receiving a series of vaccinations before going to honduras to participate in missionary work. Up to 60 percent of people with sle are diagnosed with lupus nephritis, which can lead to significant illness and even death. Sel pertahanan tubuh yang seharusnya melindungi tubuh dari masuknya kuman atau gangguan eksternal lainnya justeru menyerang tubuh pemiliknya. Systemic lupus erythematosus sle is an autoimmune disease that can affect many organs, including the skin, joints, the central nervous system and the kidneys. Systemic lupus erythematosus sle is a severe, chronic. Namun, kondisinya bisa dikontrol secara efektif tanpa flareup dengan. Pathogenesis and clinical features, eular textbook on rheumatic diseases, pp. Treatment of systemic lupus erythematosus sle has several goals.
On the one hand, in its absence, a systemic autoimmune disease develops. Jun 30, 2008 systemic lupus erythematosus sheelendra shakya dept. Common symptoms include painful and swollen joints, fever, chest pain, hair loss, mouth ulcers, swollen lymph nodes, feeling tired, and a red rash which is. Therapeutic plasma exchange as management of complicated. Sep 30, 2016 systemic lupus erythematosus sle is a chronic multisystem autoimmune disorder in which 20 % of patients are diagnosed in childhood. Systemic lupus erythematosus, the most common form of lupus, is a chronic autoimmune disease that can cause severe fatigue and joint pain. The aims of disease management with early immunosuppression are to decrease disease activity and improve quality of life. Biasanya dalam bentuk malar butterfly rash, ditandai dengan eritema pada tulang pipi dan jembatan hidung. Dec 20, 2019 systemic lupus erythematous sle is a condition in which the immune system mistakenly attacks normal cells an autoimmune condition. Systemic lupus erythematosus sle clinical presentation. The diagnosis and treatment of systemic lupus erythematosus. Penyakit lupus terbagi ke dalam beberapa jenis, antara lain. Systemic lupus erythematosus sle berat pada lakilaki.
Acute cutaneous lupus erythematosus acle lesions can be localized or generalized. Penyakit sle masih tergolong penyakit yang awam di indonesia. The name systemic lupus erythematosus dates back to the early 20th century. Lupus eritematosus sistemik systemic lupus erythematosus sle lupus ini terjadi secara menyeluruh sistemik pada tubuh penderita dan merupakan jenis lupus yang paling sering terjadi. Systemic lupus erythematosus sle is an autoimmune disease in which the bodys immune system mistakenly attacks healthy tissue. Systemic lupus erythematosus combines basic science with clinical science to provide a translational treatment of the disease and is a useful reference for specialists in the diagnosis and management of patients with sle, a tool for measurement of clinical activity for pharmaceutical development and basic research of the disease and a reference.
Pseudopseudo meigs syndrome includes patients with systemic lupus erythematosus and enlarged ovaries. Systemic lupus erythematosus is an autoimmune disease that affects many systems, including the skin, musculoskel etal, renal, neuropsychiatric, hematologic, cardiovascular, pulmonary, and. Salah satu penyakit autoimun yang banyak dikenal dan ditemui di masyarakat adalah penyakit lupus atau systemic lupus erythematosus sle. Systemic lupus erythematosus sle, also known simply as lupus, is an autoimmune disease in which the bodys immune system mistakenly attacks healthy tissue in many parts of the body.
Its presentation and course are highly variable, ranging from indolent to fulminant. Tugas mata kuliah patologi tentang penyakits ystemic lupus erythematosus sle. Pdf systemic lupus erythematosus 2014 researchgate. Systemic lupus erythematosus sle is a chronic, occasionally lifethreatening, multisystem disorder. Systemic lupus erythematosus sle is a chronic disease that causes inflammation in connective tissues, such as cartilage and the lining of blood vessels, which provide strength and flexibility to structures throughout the body. May 19, 2016 systemic lupus erythematosus sle is a chronic multisystem autoimmune disease with a highly variable clinical course 1,2. Versi lain adalah selenasledai memasukan faktor penilaian flare. Hyponatremia in patients with systemic lupus erythematosus. Discoid lupus erthematosus, adalah jenis lupus yang menyerang jaringan.
Systemic lupus erythematosus is a chronic autoimmune condition that causes inflammation in the bodys tissues. The word lupus is derived from the latin word for wolf and it refers to the characteristic butterflylike rash on the face, which is similar to the white markings on a wolfs face. The many faces of this disease make its history unique and fascinating. History of systemic lupus erythematosus sciencedirect. Systemic lupus erythematosus sle, lupus is the prototype of systemic autoimmune disease ad. Systemic lupus erthematosus sle, merupakan jenis lupus yang paling sering terjadi. Common manifestations may include arthralgias and arthritis, raynaud phenomenon, malar and other rashes, pleuritis or pericarditis, renal or cns involvement, and hematologic cytopenias. A case of lupus systemic lupus erythematosus erin douglas. Abnormalitas imunologi pada sle meliputi kemampuan untuk menghasilkan. Systemic lupus erythematosus sle is an autoimmune disease with a prevalence of 36. Systemic lupus erythematosus lupus systemic lupus erythematosus is a disease that causes your bodys immune system to attack its own cells and tissues.
Among the group of autoimmune diseases with severe multisystemic compromise, systemic lupus erythematosus sle. Systemic lupus erythematosus, atau biasa disingkat sle adalah salah satu jenis penyakit lupus yang menyebabkan peradangan di hampir seluruh organ tubuh, seperti sendi, kulit, paruparu, jantung, pembuluh darah, ginjal, sistem saraf, dan selsel darah. Discoid lupus erythematosus dle, sometimes called chronic cutaneous lupus erythematosus, is a form of lupus that affects only the skin. Systemic lupus erythematosus treatment market potential. Tujuan penelitian ini adalah untuk mengetahui faktorfaktor yang berhubungan dengan kelelahan pada pasien. Systemic lupus erythematosus disease activity index sledai adalah indeks aktivitas penyakit global yang dikembangkan dan diperkenalkan tahun 1985. If you continue browsing the site, you agree to the use of cookies on this website. The disease has been studied in dogs as the animal model for sle in humans. Diagnosis and management of systematic lupus erythematosus. Permasalah dalam penelitian ini adalah faktorfaktor apakah yang berhubungan dengan kelelahan pada pasien sle. Systemic lupus erythematosus in children and adolescents psle is a multisystem autoimmune disease with a great variability in disease presentation and course.
The booklet describes the disease and its symptoms and contains information about diagnosis and treatment as well as current. Childhoodonset sle is associated with higher morbidity and mortality than adultonset sle. In this condition, raised, round, red rashes occur, sometimes progressing to some loss of the skin with scarring and hair loss in affected areas. Sle is an autoimmune diseasea disorder in which the bodys immune system attacks the bodys own cells and organs. And it can affect organs such as the skin, kidneys, lungs, and brain. Th e systemic form was further established by osler in baltimore and jadassohn in vienna. Mar 18, 2020 systemic lupus erythematosus sle is a chronic autoimmune disease that can affect almost any organ system. Systemic lupus erythematosus sle di yayasan lupus indonesia panggon kupu semarang dapat diselesaikan dengan baik. Gejala ini sangat beragam, karena tergantung organ mana yang terkena lupus. The hallmark feature of acle is localized to the malar region butterfly rash and is characterized by confluent, macular or papular erythema lasting days to weeks that occurs symmetrically on the cheeks and bridge of the nose, sparing the nasolabial folds figure 801.
Systemic lupus erythematosus sle is one of the most complex autoimmune systemic diseases. Systemic lupus erythematosus sle musculoskeletal and. Medical condition systemic lupus erythematosus lupus. Patients may present with a wide array of symptoms, signs, and laboratory findings and have a variable prognosis that depends upon the disease severity and type of organ involvement. Namun, tanda dan gejala penyakit lupus yang paling khas adalah ruam wajah yang menyerupai sayap kupukupu ruam di kedua pipi yang disebut juga sebagai malar rash. The reason why this happens is not well understood, but certain medications, smoking and having a family member with sle all increase the risk of a person developing this condition. Symptoms of neuropsychiatric systemic lupus erythematosus may range. Systemic means that it affects many organs of the body. Immune system activation in sle is characterized by exaggerated bcell and tcell responses and loss of immune tolerance against selfantigens. Systematic lupus erythematosus, connective tissue disorder sle, nsaid. Penyakit lupus atau sle ini memiliki gejala dan tampilan klinis yang beragam sehingga dalam menegakan diagnosis lupus harus memenuhi kriteriakriteria tertentu. Systemic lupus erythematosus sle is a chronic multisystem autoimmune disease predominantly affecting women of childbearing age. Enable javascript to view the expandcollapse boxes.